Rubinstein lab

Neurodevelopmental disorders are the leading cause of morbidity in children, including cognitive impairment, severe epilepsy, and autistic features. While tremendous advancements in genetic studies have identified the involvement of many genes in the etiology of these disorders, the pathways leading from these mutations to abnormal brain function are limited. Using mouse models we unveil the neuronal basis of these severe diseases and develop novel treatment options, including gene therapy.